Mae Kingzette Shi-Kang Zhai Periannan Sethupathi, M.D. Domenick Kennedy Erica Flemming Mallory Paynich Wonbeom Paik Dr. Ute Osmers Dr. Yougang Zhai Dr. Sara Jones

To find out about our on-going projects,
click on our photos or scroll down to the lab directory below!

Dennis Lanning

Dr. Dennis Lanning

The role of the intestinal microbiota in diversification of the rabbit primary antibody repertoire

 

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Pi-Chen Yam

Pi-Chen Yam 

In situ localization of intestinal bacteria in germfree GALT

 

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Mae Kingzette

Mae Kingzette 

B lymphopoiesis: Role of IL-7b, a recently identified isoforms of IL-7

 

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Shi-Kang Zhai

Shi-Kang Zhai

CDR3 spectratyping of BCR and TCR repertoires

Periannan Sethupathi, M.D.

Dr. Periannan Sethupathi

The Role of Intestinal Bacteria in Promoting GALT Development

 

Domenick Kennedy (student)

Adipocytes and the Arrest of B lymphopoiesis

Erica Fleming (student)

CRISPR/Cas generated knockouts to study B cell development


Mallory Paynich (student)

Mechanisms by which commensal bacteria promote intestinal homeostasis.

 

Wonbeom Paik Wonbeom Paik (student)

Antibodies to Block Adhesion of Clostridium difficile to Colon Epithelial Cells

 

Ute Osmers


Dr. Ute Osmers

Changes of the bonemarrow environment with age and its influence on B lymphopoiesis

Yougang Zhai


Dr. Yougang Zhai

Development of an oral vaccine against Clostridium difficile infection

Sara Jones Dr. Sara Jones

Commensal Bacteria and Intestinal Health

 

picture unavailable Dr. Julie Swartzendruber

Pehga Johnston

Dr. Pehga Johnston (former student)

 

Karina Ochoa

Karina Ochoa (former student)

 

 

Fareena Bilwani

Dr. Fareena Bilwani (former student)

 

 

Greg Robbins

Dr. Greg Robbins (former student)

Current Position:  Postdoctoral Fellow at University of North Carolina at Chapel Hill

 

Kari Serverson

Dr. Kari Serverson (former student)

 

 

Venkata

Dr. Venkata Veramilli (former student)

 

 

Britte

Dr. Britte Beaudette-Zlatanova (former post-doctoral associate)  

 

 


Dr. Paul Jasper (former student)

Current Position:  Director, Pharmaceuticals & Project Leader at RES Group Inc.

Jasper, P.J., Zhai, S-K., Kalis, S.L., Kingzette, M., and Knight, K.L.  (2003)  B lymphocyte development in rabbit: progenitor B cells and waning of B lymphopoiesis.  J. Immunology,  171(12):6372-6380.

Lanning, D., Jasper, P., and Knight, K.  (2002) IgH Haplotype Exclusion in Rabbits.  Seminars in Immunology, 14:163;229;237.

Dr. Kathy Cho (former student)

Current Position:  Post-Doctoral Fellow at Oregon Health Sciences Center

 

 

Dr. Xiaocui Zhu (former student)

Current Position:  Research Scientist in the Biology Division at Cal. Tech.

Lanning, D., Zhu, X., Zhai, S-K., and Knight, K.L., (2000)  Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection.  Immunol Rev.175:214-228. Review

Zhu, X., Boonthum, A., Zhai, S-K., Knight, K.L. (1999) B Lymphocyte selection and age-related changes in VH gene usage in mutant Alicia rabbits. J. Immunology,163:3313-3320.

Dr. Veronica Volgina (former post-doctoral fellow)

Current Position: Research Associate at the University of Chicago

Volgina, V.V., Kingzette, M., Zhai, S-K., and Knight, K.L., (2000)  A single 3' alpha hs 1,2 enhancer in the rabbit IgH locus.  J. Immunology, 165(11):6400-6405.

Dr. Helga Spieker-Polet              Retired                        (former research associate)

Spieker-Polet, H., Yam, P.C., and Knight, K.L.  (2002)  Functional analysis of I alpha promoter regions of multiple IgA heavy chain genes.  J. Immunology,  168(7):3360-3368.

Spieker-Polet, H., Yam, P.-C., Arbieva, Z., Zhai, S.-K., and Knight, K. L., (1999) In vitro induction of the expression of multiple IgA isotype genes in rabbit B cells by TGFb and IL2. J. Immunology, 162: 5380-5388.

Kingzette, M., Spieker-Polet, H., Yam, P.-C., Zhai, S.-K., (1998) Trans-chromosomal recombination within the immunoglobulin heavy chain switch region in B lymphocytes, Proc. Natl. Acad. Sci. USA, 95:11840-11845

Spieker-Polet, H., Setupathi, P., Yam, P.C. and Knight, K.L. (1995) Rabbit Monoclonal Antibodies: Generating a Fusion Partner to Produce Rabbit-Rabbit Hybridomas. Proc. Natl. Acad. Sci. 92:9348-9352.

Raman, C., Spieker-Polet, H., Yam, P.-C., Knight, K.L. (1994) Preferential VH Gene Usage in Rabbit Ig-Secreting Heterohybridomas. J. Immunology, 154:3935-3945.

Sethupathi, P., Polet, H., Spieker-Polet, H., Yam, P.C., and Knight, K.L. (1994). Development of tumors in Ek -myc transgenic rabbits: lymphoma, hepatoma, ovarian, basal cell, and embryonic carcinomas. Leukemia, 8:2144-2155.

Spieker-Polet, H., Yam, P.C., and Knight, K.L. (1993). Differential expression of thirteen IgA-heavy chain genes in rabbit lymphoid tissue. J. Immunology. 150, 5457-5465.

Sethupathi, P., Spieker-Polet, H., Yam, P.-C., and Knight, K. L. (1992), Leukemia, Lymphoma, Embryonic Carcinoma and Hepatoma Induced in Transgenic Rabbits by the c-myc Oncogene Fused with Immunoglobulin Enhancers. In Oncogene and Transgenic Correlates of Cancer Risk Assessments, C. Feros, Ed. Plenum Press, N.Y. p. 199-216.

Sethupathi, P., Spieker-Polet, H., Picken, M.M., Zaryczny, J. and Knight, K.L., (1992). Acute B-lymphoblastic leukemia. Comparative Pathology Bulletin 24:2.

Spieker-Polet, H., Sittisombut, N., Yam, P. and Knight, K. L. (1990) Rabbit major histocompatibility complex. IV. Expression of major histocompatibility complex class II genes. J. Immunogenetics, 17, 123-132.

Knight, K.L., Spieker-Polet, H., Kazdin, D.S. and Oi, V.T. (1988) Transgenic Rabbits with Lymphocytic Leukemia induced by the C-myc oncogene fused with the Immunoglobulin heavy chain enhancer. Proc. Natl. Acad. Science, 85, 3130-3134.

 

Dr. Sandy Hayes (former research-assistant professor)

Current Position: Research Scientist at the National Institute of Child Health and Human Development at the NIH

Hayes, S.M. and Knight, K.L.  (2001)  Group 1 CD1 genes in rabbit. J. Immunology, 166(1):403-410

Dr. Candace Winstead (former student)

Current Position:  Assistant Professor at California Polytechnic Institute

Winstead, C. R., Zhai, S.-K., Sethupathi, P. And Knight, K. L., (1999) Antigen-induced somatic diversification of rabbit IgH genes: Genes conversion and hyperpointmutation. J. Immunology, 162:6602-6612.

Knight, K.L. and Winstead, C.R., (1998). Organization and expression of genes encoding IgA heavy chain, secretory component and J chain. Handbood of Mucosal immunology. Eds, Mestecky, J.

Knight, K.L. and Winstead, C.R., (1997). Generation of Antibody Diversity in Rabbits. Current Opinion in Immunology, 9:228-232.

Knight, K.L. and Winstead, C.R., (1997). B cell development in rabbit, in International Reviews of Immunology, edited by H. Wortis, 15: 129-164.

Dr. Rob Barrington (former student)

Current Position: Assistant Professor at University of South Alabama

Barrington, R., Fasullo, M. and Knight, K.L. (1999) A role for RAD51 in the generation of immunoglobulin gene diversity in rabbits, J. Immunology, 162:911-919.

Knight, K.L. and Barrington, R. (1998). Somatic diversification of IgH genes in rabbit. Immunological Reviews, 162:37-47.



 


Contact Person: Dr. Katherine Knight
Last Reviewed: June 22, 2011
Created: June 21, 1995

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