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Frederick H. Wezeman, Ph.D.
Professor, Orthopaedic Surgery
Joint Professor, Department of Cell
Biology, Neurobiology and Anatomy
Associate Dean, Loyola University Graduate
School, Medical Center Campus
Director, Structure of the Human Body Medical Course |
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B.A., Biology, 1964. Hope College.
M.S., Anatomy, 1967. University of Illinois College of Medicine.
Ph.D., Anatomy, 1969. University of Illinois College of Medicine.
NIH Postdoctoral Fellow, Department of Orthopaedic Surgery
1969-1971, Rush-Presbyterian-St. Luke's Medical Center
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EMAIL |
Current
Interests |
| Alcohol-induced bone disease; osteoporosis; bone
development, growth and repair |
Laboratory
Focus |
Research is
centered on the effects of chronic alcohol consumption on skeletal function and the
development of osteoporosis. Specifically, our investigations examine the effects of
chronic alcoholism on bone cells, bone growth and turnover, and the role of
bisphosphonates and parathyroid hormone in alcohol-induced bone disease.
Current studies taking place in the laboratory include a comparative
study of various aminobisphosphonates during chronic alcohol consumption in adolescent,
adult male and female, and ovariectomized (osteoporotic) adult female rats. Other studies
focus on the effects of alcohol on the induction of the osteogenic and adipogenic lineages
arising from bone marrow mesenchymal stem cells in
vitro. In addition, the laboratory is engaged in studies on the effects of chronic
alcohol consumption on articular and epiphyseal cartilage, and histomorphometric analysis
of the microarchitecture of cancellous bone during chronic alcohol consumption. |
Publications |
| Wezeman, F. and Gong, Z. Adipogenic effect
of alcohol on human bone marrow-derived mesenchymal stem cells. Alcoholism Clin Exp Res
28(7): 1091-1101, 2004 |
Callaci, J., Juknelis, D.,
Patwardhan, A., Sartori M, Frost, N. and Wezeman, F. The effects of binge alcohol
exposure on bone resorption and biomechanical and structural properties are offset by
concurrent bisphosphonate hormone treatment. Alcoholism Clin Exp Res 28:
182-191, 2004. |
Gong, Z. and Wezeman, F.
Inhibitory effect of alcohol on osteogenic differentiation in human bone marrow-derived
mesenchymal stem cells. Alcoholism Clin Exp Res 28: 468-479, 2004 |
- Callaci, J, Juknelis, D, and Wezeman,
F. Ovariectomy-induced bone loss can be accelerated by binge alcohol treatment:
effects compensated by intermittent parathyroid hormone. Osteoporosis Int. (in
press), 2005
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| Callaci, J. et al (F. Wezeman).
Binge Alcohol Treatment Increases Vertebral Bone Loss Following Ovariectomy: Compensation
by Intermittent Parathyroid Hormone. Alcoholism: Clin Exp Res (in press), April
2006 |
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