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Edward J. Neafsey, Ph.D.

Professor

Dept. of Pharmacology and Experimental Therapeutics
 

Graduate Program Director

Neuroscience Graduate Program

B.A., Classics, 1970. Loyola University Chicago.
Ph.D., Anatomy, 1976. University of California-Los Angeles.

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Current Interests

Neurotoxicity of ethanol, HIV gp120, amyloid-beta and beta-carbolines; emotional and autonomic changes in PTSD.

Laboratory Focus

Current research (in collaboration with Dr. Michael Collins of Biochemistry) on ethanol's neurotoxicity is using both in vivo and in vitro systems to quantify brain damage in the entorhinal cortex, dentate gyrus of the hippocampus, and olfactory bulb due to ethanol treatment. Recent results have shown that furosemide, a common diuretic drug that prevents brain edema during ethanol withdrawal, also greatly reduces ethanol brain damage. A second ethanol research project is investigating ethanol's ability to prevent neurotoxicity due to the HIV protein known as gp120 and that due to the amyloid-beta protein linked to Alzheimer's Disease.

Studies are also underway on the emotional symptoms of Post-traumatic Stress Disorder (PTSD) in Bosnian refugees.

Publications


Belmadani A, Kumar S,Schipma M, Collins MA, and Neafsey EJ. 2004
Inhibition of amyloid-beta-induced neurotoxicity and apoptosis by
moderate ethanol preconditioning. Neuroreport 15:2093--2096.

Spahic-Mihajlovic A, Crayton JW, and Neafsey EJ. 2005.
Selective Numbing and Hyperarousal in Male and Female Bosnian
Refugees with PTSD. J Anx Disorders 19:383--402.
Belmadani, A and Neafsey, EJ and Collins, MA.  Human
immunodeficiency virus type 1 gp120 and ethanol coexposure in rat
organotypic brain slice cultures: Curtailment of gp120-induced
neurotoxicity and neurotoxic mediators by moderate but not high
ethanol concentrations. J Neurovirol 9:45-54, 2003.
Belmadani A, Kumar S, Schipma M, Collins MA, and Neafsey EJ.
Inhibition of amyloid-beta-induced neurotoxicity and apoptosis by
moderate ethanol preconditioning. Neuroreport 15:2093--2096, 2004.
Spahic-Mihajlovic A, Crayton JW, and Neafsey EJ.  Selective
Numbing and Hyperarousal in Male and Female Bosnian Refugees with
PTSD. J Anx Disorders 19:383-402, 2005.

 

Last Reviewed: December  2008

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