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Edward
J. Neafsey, Ph.D.
Professor
Department
of Cell Biology, Neurobiology and Anatomy
Graduate
Program Director
Interdepartmental
Neuroscience Graduate Program
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B.A., Classics, 1970. Loyola University Chicago.
Ph.D., Anatomy, 1976. University of California-Los Angeles.
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EMAIL |
Current Interests |
| Neurotoxicity of ethanol, HIV
gp120, amyloid-beta and beta-carbolines; emotional and autonomic changes in PTSD. |
Laboratory
Focus |
| Current research (in collaboration
with Dr. Michael Collins of Biochemistry) on ethanol's neurotoxicity is using both in
vivo and in vitro systems to quantify brain damage in the entorhinal cortex,
dentate gyrus of the hippocampus, and olfactory bulb due to ethanol treatment. Recent
results have shown that furosemide, a common diuretic drug that prevents brain edema
during ethanol withdrawal, also greatly reduces ethanol brain damage. A second ethanol
research project is investigating ethanol's ability to prevent neurotoxicity due to the
HIV protein known as gp120 and that due to the amyloid-beta protein linked to Alzheimer's
Disease. Studies are also underway on the emotional symptoms of Post-traumatic Stress
Disorder (PTSD) in Bosnian refugees.
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Publications |
Belmadani A, Kumar S,Schipma M, Collins MA, and Neafsey EJ. 2004
Inhibition of amyloid-beta-induced neurotoxicity and apoptosis by
moderate ethanol preconditioning. Neuroreport 15:2093--2096.
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Spahic-Mihajlovic A, Crayton JW,
and Neafsey EJ. 2005.
Selective Numbing and Hyperarousal in Male and Female Bosnian
Refugees with PTSD. J Anx Disorders 19:383--402. |
Belmadani, A and Neafsey,
EJ and Collins, MA. Human
immunodeficiency virus type 1 gp120 and ethanol coexposure in rat
organotypic brain slice cultures: Curtailment of gp120-induced
neurotoxicity and neurotoxic mediators by moderate but not high
ethanol concentrations. J Neurovirol 9:45-54, 2003. |
Belmadani A, Kumar S, Schipma M, Collins MA, and Neafsey
EJ.
Inhibition of amyloid-beta-induced neurotoxicity and apoptosis by
moderate ethanol preconditioning. Neuroreport 15:2093--2096, 2004. |
Spahic-Mihajlovic A, Crayton JW, and Neafsey EJ.
Selective
Numbing and Hyperarousal in Male and Female Bosnian Refugees with
PTSD. J Anx Disorders 19:383-402, 2005. |
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