|
Gwendolyn L. Kartje, M.D.,
Ph.D.
Chief, Neurology Service, Hines VA
Professor,
Department
of Pharmacology and
Experimental Therapeutics |
|
B.S., Biology, Northern Illinois University, 1976.
Ph.D., Anatomy, Loyola University, 1984.
M.D., Loyola University Chicago, Stritch School of Medicine, 1988.
|
Current
Interests |
| Neuronal plasticity and recovery of function after
stroke and spinal cord injury |
Laboratory
Focus |
The overall
goal of our research program is to use translational approaches to improve functional
recovery after neural injury by enhancing neuronal plasticity, i.e. the ability of the
intact part of the brain to take over for the damaged area. This laboratory uses the
rodent focal ischemic model to investigate recovery after stroke, or the drop-weight
method of injury to investigate mechanisms of recovery after spinal cord injury. A
variety of methods to enhance neural plasticity and repair are tested, i.e. blockade of
the major neurite growth inhibitory protein Nogo-A, pharmacologic methods paired with
rehabilitation, and adult human bone marrow stem cell treatment. Functional outcome
is then assessed using a battery of behavioral tests and outcome is correlated with
anatomical tracing to determine axonal plasticity of spared neuronal pathways, dendritic
plasticity using the golgi-cox method, or electrophysiological methods to directly
stimulate and map new neuronal connections. |
Publications |
W.
J. Z'Graggen, K. Fouad, O. Raineteau, G.A.S. Metz, M.E. Schwab and G.L. Kartje,
Compensatory sprouting and electrophysiological re-routing after unilateral pyramidal
tract lesion in neonatal rats, J. Neuroscience, 20: 6561-6569, 2000. |
C..M.
Papadopoulos, S-Y. Tsai, T. Alsbiei, T.E. O’Brien, M.E. Schwab and G.L. Kartje,
Functional recovery and neuroanatomical plasticity following middle cerebral artery
occlusion and IN-1 antibody treatment in the adult rat, Annals of Neurology, 51: 433-441,
2002. |
A.
Emerick, E.J. Neafsey, M.E. Schwab and G.L. Kartje, Functional reorganization of
the motor cortex in adult rats after cortical lesion and treatment with mAb IN-1, J.
Neuroscience, 23: 4826-4830, 2003. |
| A. Emerick and G.L. Kartje, Behavioral
recovery and anatomical plasticity in adult rats after cortical lesion and treatment with
monoclonal antibody IN-1, Behavioral Brain Research, 152: 315-325, 2004. |
Book Chapters |
| G.L. Kartje and M.E.
Schwab, Axonal Growth in the Adult Mammalian Nervous System: Regeneration and Compensatory
Plasticity, In: Basic Neurochemistry, 7th edition, Siegel, G., (ed),
Lippincott, 2005. |
| T.M. Markus, S-Y Tsai,
M.R. Bollnow, R.G. Farrer, T.E. O'Brien, D.R. Kindler-Baumann, M. Rudin, C. Wiessner, A.K.
Mir, M. E. Schwab and G. L. Kartje. Recovery and brain reorganization after
stroke in adult and aged rats. Ann Neurol. Dec: 58 (6):950-3, 2005 |
| C. Wiessner, G.L. Kartje,
R. Hillenbrand, A.K. Mir and M.E. Schwab, Anti-Nogo-A antibody therapy after experimental
stroke. Pharmacology of Cerebral Ischemia, Krieglstein J. Klumpp S., (ed),
Medpharm Scientific Publishers, Stuttgart: 343-54, 2002. |
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