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Gwendolyn L. Kartje, M.D., Ph.D.

Chief,  Neurology Service, Hines VA

Professor,

Department of Pharmacology and

Experimental Therapeutics

KartjeGwendolynM.D.Ph.D-1tif (6031590 bytes)

B.S., Biology,  Northern Illinois University, 1976.
Ph.D., Anatomy,  Loyola University, 1984.
M.D.,  Loyola University Chicago, Stritch School of Medicine, 1988.

 

Current Interests

Neuronal plasticity and recovery of function after stroke and spinal cord injury

Laboratory Focus

The overall goal of our research program is to use translational approaches to improve functional recovery after neural injury by enhancing neuronal plasticity, i.e. the ability of the intact part of the brain to take over for the damaged area.  This laboratory uses the rodent focal ischemic model to investigate recovery after stroke, or the drop-weight method of injury to investigate mechanisms of recovery after spinal cord injury.  A variety of methods to enhance neural plasticity and repair are tested, i.e. blockade of the major neurite growth inhibitory protein Nogo-A, pharmacologic methods paired with rehabilitation, and adult human bone marrow stem cell treatment.  Functional outcome is then assessed using a battery of behavioral tests and outcome is correlated with anatomical tracing to determine axonal plasticity of spared neuronal pathways, dendritic plasticity using the golgi-cox method, or electrophysiological methods to directly stimulate and map new neuronal connections.

Publications

W. J. Z'Graggen, K. Fouad, O. Raineteau, G.A.S. Metz, M.E. Schwab and G.L. Kartje, Compensatory sprouting and electrophysiological re-routing after unilateral pyramidal tract lesion in neonatal rats, J. Neuroscience, 20: 6561-6569, 2000.

C..M. Papadopoulos, S-Y. Tsai, T. Alsbiei, T.E. O’Brien, M.E. Schwab and G.L. Kartje, Functional recovery and neuroanatomical plasticity following middle cerebral artery occlusion and IN-1 antibody treatment in the adult rat, Annals of Neurology, 51: 433-441, 2002.

A. Emerick, E.J. Neafsey, M.E. Schwab and G.L. Kartje, Functional reorganization of the motor cortex in adult rats after cortical lesion and treatment with mAb IN-1, J. Neuroscience, 23: 4826-4830, 2003.

A. Emerick and G.L. Kartje, Behavioral recovery and anatomical plasticity in adult rats after cortical lesion and treatment with monoclonal antibody IN-1, Behavioral Brain Research, 152: 315-325, 2004.

Book Chapters

G.L. Kartje and M.E. Schwab, Axonal Growth in the Adult Mammalian Nervous System: Regeneration and Compensatory Plasticity, In: Basic Neurochemistry, 7th edition, Siegel, G., (ed), Lippincott, 2005.
T.M. Markus, S-Y Tsai, M.R. Bollnow, R.G. Farrer, T.E. O'Brien, D.R. Kindler-Baumann, M. Rudin, C. Wiessner, A.K. Mir, M. E. Schwab and G. L. Kartje.  Recovery and brain reorganization after stroke in adult and aged rats. Ann Neurol. Dec: 58 (6):950-3, 2005
C. Wiessner, G.L. Kartje, R. Hillenbrand, A.K. Mir and M.E. Schwab, Anti-Nogo-A antibody therapy after experimental stroke.  Pharmacology of Cerebral Ischemia, Krieglstein J. Klumpp S., (ed), Medpharm Scientific Publishers, Stuttgart: 343-54, 2002.

 

Last Reviewed: December  2008

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