|
Allen Mark Samarel,
M.D.
Director of Research
William B. Knapp Professor of
Medicine and Physiology
Cardiac hypertrophy in response to pressure or volume
overload is an independent risk factor for the development of congestive heart
failure and sudden cardiac death. The overall goals of Dr. Samarel's research
program are to elucidate, at the cellular and molecular level, the causes and
consequences of myocardial hypertrophy using a variety of experimental
approaches. His laboratory has concentrated on the role of mechanical and
neurohormonal signals in initiating and sustaining the hypertrophic response,
and in determining the reasons for the transition from stable cardiac
hypertrophy to heart failure.
Representative
current projects:
-
identifying the signal transduction pathways regulating
neurohormonal and mechanical
alterations in myosin heavy chain gene transcription in cultured heart
cells;
-
determining how mechanical and
neurohormonal signals regulate sarcomere assembly, disassembly and degradation;
-
characterizing the signaling pathways responsible for alterations in cardiac myocyte Ca transporter gene
expression during hypertrophy and heart failure.
 |
 |
| Control
neonatal rat ventricular myocyte in serum-free culture |
Neonatal rat
ventricular myocyte treated with the hypertrophic agonist endothelin-1
(100nM, 48h) |
View a partial list of
Dr. Samarel's publications through the National Library of Medicine's
PubMed online database.
Address:
The Cardiovascular Institute
Loyola University Chicago
Building 110, Room 5222
2160 South First Avenue
Maywood, Illinois 60153
V: (708) 327-2821
F: (708) 327-2849
E: asamare@lumc.edu
|
