|
Investigators |
Funding Source |
Title |
Description |
|
J Akar |
Medtronic |
Biventricular Evaluation of
Endothelial Function (BEEF) |
To study the effect of BEEF in
patients with congestive heart failure |
|
KL Byron
L Cribbs |
NIH/NHLBI |
Calcium Entry and Vascular Smooth
Muscle Excitation |
To identify non-selective cation
currents in arterial smooth muscle cells and determine their roles
in vasopressin-induced action potential generation. |
|
L Cribbs |
NIH/NHLBI |
T-Type Ca Channels in Development and Cell Proliferation |
To
understand the role of T-type Ca channels in the cardiovascular
system with particular focus on instances where they appear to
predominate and have unique functions over high voltage-activated,
L-type channels. |
A Goodman
L Cribbs |
American Heart Association |
Altered
Mechanotransduction Signaling in Type 2 Diabetes and Diabetic
Cardiomyopathy |
To determine what mechanotransduction
signaling molecules are differentially regulated in the heart as a
result of diabetes and to look specifically at the regulation of
PYK2 in the diabetic milieu |
|
WP Jeske |
Caden
Biosciences |
Antiplatelet Effect of PAR-1 Inhibitors |
To determine whether a specific
series of small molecules modulate platelet-activation response. |
WP Jeske
JM Walenga
J Fareed
D
Hoppensteadt
M Bakhos |
PolyMedix |
Novel
Heparin Antagonists |
To create a comparative
neutralization profile of unfractionated heparin by PolyMedix's
novel site-directed antagonists |
SL Lipsius
AM Samarel |
NIH/NHLBI |
Beta-Adrenergic Receptor Function in Atrial Myocytes |
To test the hypothesis that the
ECM-integrin-cytoskeletal complex remodels beta-adrenergic receptor
function in atrial myocytes. |
|
J Martin |
Hines VA
Hospital |
Serotonin
Therapy for Parkinson's Disease and Neurodegenerative Disorders |
To develop and produce adeno-associated
virus vector genetic constructs for the purpose of developing a
novel model of progressive neuronal degeneration as seen in
Parkinson's disease.
(subcontract with
Hines VA Hospital for which Dr. William Wolf is principal
investigator) |
|
J Martin |
Illinois
Department of Public Health |
Human Adult
Bone Marrow-Derived Stem Cell Therapy for Recovery from Ischemic
Stroke |
To develop and produce adeno-associated
virus vector genetic constructs.
(subcontract with Hines VA Hospital
for which Dr. Gwendolyn Kartje is principal investigator) |
|
R Mestril |
NIH/NHLBI |
Cardioprotection
against Endotoxins |
To
study the mechanism by which hsp70 protects cardiomyocytes against
endotoxin-induced injury. |
AM Samarel
J Martin |
NIH/NHLBI |
Mechanical Activity and Myocyte Remodeling
|
To
investigate the
role of focal adhesion proteins and costameric components in
cardiomyocyte remodeling in response to linear and transverse
stretch.
(subcontract with the University of Illinois at Chicago, a
component of a P01
(Integrated mechanisms of cardiac maladaptation)
for which Dr. John Solaro is principal investigator and Dr. Brenda
Russell is project leader) |
AM Samarel
KK Henderson |
T3 Therapeutics and King Pharmaceuticals |
T3 Rx During Post-infarction LV
Remodeling |
To develop a post-myocardial infarction
model to facilitate study of the use of T3 in the treatment of
congestive heart failure. |
JM Walenga
WP Jeske
MM Prechel |
Mitsubishi Pharmaceuticals |
HIT Registry |
To create and maintain the Loyola
Registry of Heparin-Induced Thrombocytopenia (HIT) in Cardiovascular
Surgery Patients, the only available database of its kind in existence. |
JM Walenga
D
Hoppensteadt |
Pentapharm |
PiCT Evaluation |
To compare the performance of Pefakit
PiCT (Pentapharm) to Heptest (Haemachem). |
JM Walenga
WP Jeske
MM Prechel
D
Hoppensteadt |
Sanofi-Aventis |
Differentiation of LMWHs |
Pharmacologic characterization and
differentiation of low molecular weight heparins and heparin-derived
oligosaccharides. |
