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Jody L. Martin,
Ph.D.
The heart is a complex organ that responds to different stresses by
activating different signaling pathways. Some of the kinases which are
activated in response to ischemic stress potentially regulate the
modification of the small heat shock proteins (hsps). Heat shock
proteins (hsps) are induced by noxious stresses, like heat, and are
protective against these stresses. We are primarily concerned with two
small hsps, alpha B-crystallin and hsp27, which are present at rather
high levels in the heart. These small hsps are protective against
ischemia and other stresses in cardiomyocytes. The altered
phosphorylation of the small hsps in response to stress on the heart is
thought to regulate cellular localization and possibly the function of
these proteins. We are examining the role of these post-translational
modifications by mutagenesis and adenoviral expression of the small hsps
in cardiomyocytes as well as utilizing transgenic models. Furthermore we are examining the multiple kinases putatively
responsible for the post translational modification of the small hsps.
The pattern of activation and in fact which kinases actually act on
these proteins, in vivo, is under active investigation. View a partial list of
Dr. Martin's publications through the National Library of Medicine's
PubMed online database. Address:
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©1995-2004 Loyola
University Health System. All rights reserved. |
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