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Kyle K. Henderson,
Ph.D.
Assistant Professor of Medicine
Cardiovascular
disease (CVD) is the leading cause of death in industrialized nations. Within
13yrs it may become the leading cause of morbidity and mortality in the world.
The etiology of CVD is rapidly improving with vascular physiologists utilizing
the latest in molecular/genetic technology. The overall goal of Dr. Henderson’s
research is to elucidate, from the whole animal to the molecular level, the
mechanisms responsible for adaptive and maladaptive left ventricular
re-modeling. Dr. Henderson’s research begins with two distinct rodent models of
CVD. The first animal model uses coronary artery ligation to induce a
myocardial infarction (MI). This study concentrates on the role of reduced
thyroid hormone levels post MI, thyroid hormone replacement, and changes in
myocardial structure, function and gene expression. The second model utilizes
an aortocaval fistula to induce volume overload of the heart. This animal model
mimics the effects of mitral valve regurgitation. The timing of mitral valve
repair or replacement is currently fraught with uncertainty. Replacing the
valve too soon prolongs exposure to the prosthetic valve and anticoagulant
therapy, but delaying surgery increases the surgical mortality rate and reduces
postoperative LV function. If valve replacement is delayed too long, the new
valve will not be tolerated for reasons which have not been clearly elucidated.
This study will focus on the time course of changes in gene expression
associated with volume overload and its reversal in the heart.
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Short Axis MI
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View a partial list of
Dr. Henderson's publications through the National Library of Medicine's
PubMed online database.
Address:
The Cardiovascular Institute
Loyola University Chicago
Building 110, Room 5227
2160 South First Avenue
Maywood, Illinois 60153
V: (708) 327-2839
F: (708) 327-2849
E: khenderson@lumc.edu
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