Frederick H. Wezeman, Ph.D.
Ph.D. University of Illinois College of Medicine, Chicago
Post-Doctoral Fellowship, Bone Research Laboratory, Department of Orthopaedic Surgery, Rush Medical Center, Chicago

Interest: Alcohol-induced bone disease and osteoporosis
Research is centered on the effects of  alcohol consumption on bone and the development of osteoporosis. Specifically, our investigations examine the effects of alcohol on bone microarchitecture, bone cell gene expression, bone growth and turnover, and the role of aminobisphosphonates (BP) and parathyroid hormone (PTH) as therapeutic agents. Current studies taking place in the laboratory include: A comparative study of BP and PTH during alcohol consumption in adolescent and adult male and female rats, and in ovariectomized osteoporotic rats; Evaluation of the effects of alcohol on the induction of the osteogenic and adipogenic lineages arising from human bone marrow mesenchymal stem cells; Micro computerized tomography (uCT) of cancellous bone microarchitecture, peripheral quantitative computerized tomography (pQCT) of bone mineral density, and vertebral biomechanical analysis in binge alcohol-induced osteoporosis; Gene microarray expression analysis of alcohol-induced bone disease.

Select Publications
View a partial list of Dr. Wezeman's publications through the National Library of Medicine's PubMed online database.